The onset of any physical exercise program causes muscle pain that can hinder movements as simple as getting up from a sofa. With time and a little persistence, the muscles become accustomed to the effort, developing more strength and endurance. Researchers affiliated with Harvard University in the United States and the University of São Paulo (USP) in Brazil describe the cellular mediator that makes this adaptation to exercise possible in the journal Cell.
The mediator is succinate, a metabolite hitherto known only for its participation in mitochondrial respiration. The authors of the article include Julio Cesar Batista Ferreira, a professor at USP’s Biomedical Sciences Institute (ICB) and a member of the Center for Research on Redox Processes in Biomedicine (Redoxome), one of the Research, Innovation and Dissemination Centers (RIDCs) funded by FAPESP (São Paulo Research Foundation), and postdoctoral fellow Luiz Henrique Bozi, who conducted the investigation while he was